The mode of action of dimeticone 4% lotion against head lice, Pediculus capitis

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The mode of action of dimeticone 4% lotion against head lice, Pediculus capitis

BACKGROUND Treatment of head lice using physically acting preparations based on silicones is currently replacing insecticide use due to widespread resistance to neurotoxic agents. It has been postulated that some products act by asphyxiation, although the limited experimental evidence and the anatomy of the louse respiratory system suggest this is unlikely. RESULTS Observation over several ho...

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What's eating you? head lice (Pediculus humanus capitis).

The head louse (Pediculus humanus capitis) is a blood-sucking arthropod of the suborder Anoplura. Infestation continues in epidemic proportions in children of all socioeconomic groups. Although not implicated as a disease vector, infestation can lead to considerable distress, missed days of school, and secondary infections. Pyrethroids are recommended for treatment, but resistance is common. Ne...

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Permethrin-resistant human head lice, Pediculus capitis, and their treatment.

OBJECTIVE To compare the pediculicidal activity of Ovide lotion and its active ingredient, 0.5% malathion, with Nix and its active ingredient, 1% permethrin, in permethrin-resistant head lice. DESIGN In vitro pediculicidal product and active ingredient comparison. The presence of knockdown resistance-type mutations (T929I and L932F) was validated by DNA sequencing. SETTING University of Mas...

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Bioactivity of Argentinean Essential Oils Against Permethrin-Resistant Head Lice, Pediculus humanus capitis

Infestation with the head louse, Pediculus humanus capitis De Geer (Phthiraptera: Pediculidae), is one of the most common parasitic infestation of humans worldwide. Traditionally, the main treatment for control of head lice is chemical control that is based in a wide variety of neurotoxic synthetic insecticides. The repeated overuse of these products has resulted in the selection of resistant p...

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Dimeticone-Based Pediculicides: A Physical Approach to Eradicate Head Lice

Resistance of head lice to insecticides with a neurotoxic mode of action, such as permethrin and malathion, is increasing in incidence and geographic extent. As a consequence, physically acting pediculicidal products have emerged. Dimeticones are synthetic silicone oils of low surface tension and can therefore coat most surfaces, thus also killing head lice (Pediculus humanus capitis) by physic...

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ژورنال

عنوان ژورنال: BMC Pharmacology

سال: 2009

ISSN: 1471-2210

DOI: 10.1186/1471-2210-9-3